Washington [US]January 11 (ANI): A crew of scientists has found new proof of the potential well being dangers of chemical compounds in tobacco smoke and marijuana.
In a examine printed on-line by EClinicalMedicine, researchers report that individuals who smoked solely marijuana had a number of poisonous chemical compounds associated to smoke of their blood and urine, however at decrease ranges than those that smoked tobacco and marijuana or solely tobacco .
Two of those chemical compounds, acrylonitrile and acrylamide, are recognized to be poisonous at excessive ranges. The researchers additionally discovered that publicity to acrolein, a chemical produced by the combustion of quite a lot of supplies, will increase with smoking however not with marijuana use and contributes to heart problems in tobacco people who smoke.
The findings recommend that top ranges of acrolein could also be an indication of an elevated danger of heart problems and that lowering publicity to the chemical may cut back that danger. That is significantly necessary for individuals contaminated with HIV, the virus that causes AIDS, given the excessive charges of smoking and the elevated danger of coronary heart illness on this group.
“Marijuana use is rising in the USA with a rising variety of states legalizing it for medical and non-medical functions, together with a further 5 states within the 2020 election. The rise has renewed considerations about attainable well being results. from marijuana smoke, which is understood to include a number of the similar poisonous combustion merchandise present in tobacco smoke, “mentioned lead examine writer Dana Gabuzda, MD, of Dana-Farber.
“That is the primary examine to match publicity to acrolein and different dangerous chemical compounds associated to smoke over time in unique marijuana people who smoke and tobacco people who smoke, and to see if these exposures are associated to heart problems.”
The examine concerned 245 HIV constructive and HIV adverse individuals in three research of HIV an infection in the USA. (Research involving individuals with HIV an infection had been used because of the excessive charges of tobacco and marijuana use on this group.)
The researchers collected knowledge from the individuals’ medical information and survey outcomes and analyzed their blood and urine samples for substances produced by the breakdown of nicotine or the burning of tobacco or marijuana. Combining these knowledge units allowed them to trace the presence of particular poisonous chemical compounds in tobacco or marijuana use and see if any had been related to an elevated danger of coronary heart illness.
The researchers discovered that individuals who completely smoked marijuana had greater blood and urine ranges of varied poisonous chemical compounds associated to smoke, similar to naphthalene, acrylamide, and acrylonitrile metabolites, than non-smokers. Nevertheless, the concentrations of those substances had been decrease in marijuana people who smoke than in tobacco people who smoke.
The researchers additionally discovered that acrolein metabolites, substances generated by the breakdown of acrolein, had been elevated in tobacco people who smoke however not in marijuana people who smoke. This enhance was related to heart problems no matter whether or not the people smoked tobacco or had different danger elements.
“Our findings recommend that top acrolein ranges can be utilized to establish sufferers with elevated cardiovascular danger,” Gabuzda mentioned, “and that lowering acrolein publicity from smoking tobacco and different sources may very well be a technique to cut back danger.” . (AND ME)
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