TUESDAY, Jan.5, 2021 (HealthDay Information) – A single intramuscular dose of ceftriaxone 500 mg is really useful for the remedy of uncomplicated urogenital, anorectal, and pharyngeal gonorrhea, in accordance with up to date tips revealed within the 18 version of December US Facilities for Illness Management and Prevention Weekly Morbidity and Mortality Report.
Noting that the 2010 tips really useful a single 250 mg intramuscular dose of ceftriaxone and a single 1 g oral dose of azithromycin for the remedy of uncomplicated gonococcal infections of the cervix, urethra and rectum, Sancta St. Cyr , MD, from the CDC in Atlanta and colleagues up to date earlier tips for treating sexually transmitted infections attributable to Neisseria gonorrhoeae. The advice was reevaluated based mostly on rising concern about antimicrobial administration and the potential impression of twin remedy on commensal organisms and concurrent pathogens, in addition to consideration of a low incidence of resistance to ceftriaxone and the next incidence of resistance to azithromycin.
The authors suggest a single 500 mg intramuscular dose of ceftriaxone for uncomplicated urogenital, anorectal, and pharyngeal gonorrhea. Concomitant remedy with doxycycline (100 mg orally twice every day for seven days) is really useful in circumstances the place chlamydial an infection has not been dominated out.
“The excessive frequency of pharyngeal gonorrhea with substantial underdetection and elevated understanding of the extensive particular person pharmacokinetic and pharmacodynamic variability has contributed to the advice for rising the dose of ceftriaxone,” the authors write.
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