Angelini Pharma Enters Into An Unique Choice Settlement With Cureverse to License World Growth and Commercialization Rights For A Novel and Revolutionary Scientific-Stage Mind Well being Asset

• The settlement grants Angelini Pharma an possibility for unique licensing rights to develop and commercialize CV-01.¹a brand new compound in section 1 medical investigation with broad potential to deal with mind well being ailments

• Cureverse receives undisclosed upfront funds and is eligible for future milestone-dependent funds and royalties, whereas retaining the rights to commercialize CV-01 within the Republic of Korea, China, Hong Kong, Macau and Taiwan.

• The collaboration builds on Angelini Pharma's robust portfolio and deep therapeutic experience in mind well being, in addition to Cureverse's early growth experience and capabilities.

ROME, Oct. 21, 2024 (GLOBE NEWSWIRE) — Angelini Pharma, a part of privately held Angelini Industries, and Cureverse Inc., an early-stage analysis and growth firm, right this moment introduced that they’ve signed an unique world possibility settlement for the event and commercialization of Cureverse's modern mind well being asset CV-01.

Below the phrases of the settlement, Angelini Pharma will lead all growth efforts for CV-01 and, after an preliminary possibility interval, could have the correct to acquire the unique world license to develop and commercialize the compound, exterior of the Republic of Korea. , China, Hong Kong, Macau and Taiwan. CV-01 is a novel and modern investigational compound that prompts protecting pathways regulated by nuclear issue erythroid 2-related 2 (Nrf2) and has nice potential to be a drug with disease-modifying properties in quite a lot of immune problems. mind well being. together with epilepsy.^Yo CV-01 is an investigational compound at the moment in a Part 1 medical trial within the Republic of Korea and is being developed by Cureverse for Alzheimer's illness.

Cureverse will obtain an upfront cost and also will be eligible to obtain further funds primarily based on predefined industrial and growth milestones of as much as approx. $360 million, in addition to tiered royalties on post-approval internet gross sales.

“Our strategic collaboration with Cureverse additional strengthens Angelini Pharma's place as an rising chief in mind well being,” stated Jacopo Andreose, CEO of Angelini Pharma. “Neurological situations similar to epilepsy are among the many main causes of illness burden worldwide.ⁱⁱ Whereas vital progress has been revamped the previous 15 years, many individuals residing with epilepsy are nonetheless unable to attain seizure management regardless of mixture remedy of a number of anti-seizure drugs.^III “Via the event of CV-01 and probably different compounds, we goal to supply much-needed options to individuals residing with mind well being points world wide.”

“Our analysis has revealed the exceptional potential of CV-01 to remodel the panorama of mind well being, from epilepsy to Alzheimer's and Parkinson's illness,” stated Sung Jin Cho, CEO of Cureverse Inc. “We’re really delighted to partnering with Angelini Pharma on this journey. Their deep therapeutic experience and dedication to mind well being align completely with our imaginative and prescient. Collectively, we aren’t solely growing a remedy, we’re paving the best way for a future through which sufferers. with neurological situations have entry to therapies that can really change their lives.”

About mind well being
Mind well being as a therapeutic space contains each neurological and psychological well being situations.^IV Mind well being is outlined by the World Well being Group as a state of mind functioning within the cognitive, sensory, socio-emotional, behavioral and motor domains, which permits an individual to develop their full potential all through their life, no matter its presence or absence. of problems.^v

Mind well being represents an pressing world well being precedence. An estimated 179 million Europeans stay with mind well being issues^{I noticed} and greater than 18% of all well being loss worldwide is related to mind situations.^viii Moreover, mind well being situations are liable for appreciable particular person, financial, and societal impression, together with lack of independence, lowered productiveness, strained relationships, elevated danger of suicide, and excessive healthcare prices.^viii There may be an pressing want to lift consciousness and cut back stigma, prejudice and discrimination to make sure that mind well being is valued, promoted and guarded for all.^v

About epilepsy
Epilepsy is without doubt one of the most widespread neurological ailments on this planet, affecting roughly 50 million individuals of all ages.^ix It’s estimated that in Europe as much as six million individuals stay with this illness.^unknown Epilepsy can have a number of potential causes, together with structural, metabolic, genetic, and different elements, though roughly half of instances worldwide don’t have any recognized trigger.^ix

Problems related to epilepsy are critical, with a danger of untimely mortality as much as thrice increased than that of the final inhabitants.^ix The recurrent seizures related to this situation even have wide-ranging results on an individual's general bodily and psychological well being, training and employment alternatives, and different high quality of life elements. ^ix

Remedies can be found to assist cut back seizures and enhance high quality of life; Nonetheless, roughly 40% of individuals residing with epilepsy are nonetheless uncontrolled regardless of remedy with two anti-seizure drugs.^III

About Angelini Pharma
Angelini Pharma is a world pharmaceutical firm that’s a part of the non-public multi-business Angelini Industries. The Firm researches, develops and markets well being options with a concentrate on the areas of Mind Well being, together with Psychological Well being and Epilepsy, and Shopper Well being. Based in Italy at the start of the 20th century.^th century, Angelini Pharma operates straight in 20 nations and employs greater than three,000 individuals. Its merchandise are marketed in additional than 70 nations by means of strategic alliances with the principle worldwide pharmaceutical teams. For extra details about Angelini Pharma, go to https://www.angelinipharma.com.

About Angelini Industries
Angelini Industries is a multinational industrial group based in Ancona in 1919 by Francesco Angelini. Immediately, Angelini Industries represents a stable and diversified industrial actuality that employs roughly 5,800 workers and operates in 21 nations world wide with revenues of greater than 2 billion euros, generated within the well being, industrial expertise and items sectors. of consumption. A particular funding technique for progress; fixed dedication to analysis and growth; A deep information of the markets and sectors of exercise make Angelini Industries one of many Italian firms of excellence within the sectors through which it operates. For extra data, go to www.angeliniindustries.com.

About Cureverse Inc.
Based in 2021, Cureverse has shortly change into a key innovator within the Korean biotech panorama, with a daring imaginative and prescient to revolutionize mind well being on a worldwide scale. Specializing in cutting-edge small molecule therapies, Cureverse is targeted on addressing central nervous system (CNS) problems, similar to Alzheimer's illness (AD), with the objective of bringing hope to hundreds of thousands of individuals world wide. Whereas many AD drugs have hit the market, no actual breakthrough has but been made…till now. On the heart of our innovation is CV-01, a “first-in-class” remedy that completely targets the Keap1/Nrf2 pathway, activating Nrf2 by means of exact modulation. This strategy gives unprecedented selectivity, successfully controlling neuroinflammation with a precision unmatched by current therapies. Together with CV-01, Cureverse is actively advancing CV-02, an S1P1 bias agonist that’s now IND-ready, in addition to a number of promising follow-on non-clinical applications. With latest IND approvals and powerful medical progress, Cureverse is properly positioned to remodel the best way we deal with neurological situations and enhance the lives of sufferers world wide.

Media contact
Chiara Antoniucci
World Director of Model and Media Communications, Angelini Pharma
Phone: +39 3477133926
Electronic mail: chiara.antoniucci@angelinipharma.com

Sung Jin Cho
CEO of Cureverse Inc.
Electronic mail: sjcho@cureverse.co.kr, sjcho@kist.re.kr

________________________________

¹ CV-01 is an investigational compound, not accepted to be used by regulatory authorities.

^Yo Archived knowledge from Cureverse.
ⁱⁱ Institute of Well being Metrics and Analysis. World burden of ailments that have an effect on the nervous system. Accessible at: https://www.healthdata.org/research-analysis/library/global-burden-conditions-affecting-nervous-system Final entry: October 2024.
^III Chen Z, Brodie MJ, Liew D, Kwan P. Therapy outcomes in sufferers with newly identified epilepsy handled with new and established antiepileptic medicine: a 30-year longitudinal cohort examine. JAMA Neurol. March 1, 2018; 75 (three): 279-286.
^IV Winkler AS et al. Lancet Glob Well being. 2024;12(5):e735-e736.
^v World Well being Group. Optimizing mind well being throughout the lifespan: WHO place paper. Geneva: World Well being Group; 2022.
^{I noticed} Nutt D, et al. Eurosalud (Int) 2017;23:21–5.
^viii Institute of Well being Metrics and Analysis. Understanding mind well being world wide. Accessible at: https://brainhealthatlas.org/ Final entry: October 2024.
^viii World Well being Group. World psychological well being report: reworking psychological well being for all. Geneva: World Well being Group; 2022.
^ix WHO. “Key information about epilepsy.” Np, February 9, 2023. Net. August 24, 2023.
^unknown Behr et al. Epidemiology of epilepsy. Neurological overview January 2016; 172(1):27-36. doi: 10.1016/j.neurol.2015.11.003.