An optimum vaginal microbiome is a key issue for gynecological, urogenital and reproductive well being
VS-01™ is a multi-strain probiotic and prebiotic clinically validated to determine an optimum vaginal microbiome and keep regulated vaginal pH.
Based mostly on analysis from famend vaginal microbiome scientist Dr. Jacques RavelVS-01™ is the primary to pioneer a most complete technology-driven microbial genomics method Vaginal Host Microbiome Dataset
THE ANGELS, Might 21, 2024 /PRNewswire/ — Seed well beinga microbiome science firm, at present launched VS-01™ Vaginal Synbiotic, the primary vaginal synbiotic clinically validated to quickly set up an optimum vaginal microbiome dominated by Lactobacillus curlatus probably the most protecting micro organism within the vagina. Dr. Jacques Ravel Pioneering analysis has elucidated the essential position of the vaginal microbiome in gynecological, urogenital and reproductive well being, though on a regular basis elements akin to stress, intercourse, menstruation and weight loss plan can upset its stability and deplete the abundance of L. crispatus. Dr. Ravel's intensive medical knowledge set signifies that 90% of girls lack a steady microbiome dominated by L. crispatus, a key consider vaginal well being. Developed from Dr. Ravel's discovery that not all strains of L. crispatus are equally protecting, VS-01™ is formulated with an ecology of three proprietary strains of L. crispatuswhich have been recognized from over 600 candidate probiotic strains for his or her superior efficacy in holding pH regulated and selling steady vaginal well being.
VS-01™ Vaginal Symbiotic
VS-01™ Vaginal™ Synbiotic SMART Pill
The launch builds on Seed's award-winning portfolio of microbiome-targeted improvements and expands the corporate's product portfolio past the intestine.
“This launch represents the very essence of why we based Seed: translating pioneering microbiome discoveries into life-changing well being improvements,” he stated. ara katz, co-founder and co-CEO of Seed Well being. “As a girl and mom, it’s particularly significant to speed up advances in an space that has been so deprioritized and systematically missed. The vaginal microbiome is the subsequent frontier in girls's well being, and VS-01™ embodies its huge potential: a totally new paradigm of care answer that empowers better company over our our bodies.”
The following frontier in vaginal well being
Dr. Ravel's discoveries over the previous twenty years have been instrumental in understanding the vaginal microbiome. His 2012 landmark research confirmed that probably the most steady and optimum vaginal microbiome is dominated by micro organism: L. crispatus. Nevertheless, on a regular basis elements akin to menstruation, sexual exercise, train, stress, in addition to contraceptives and cleansing merchandise, alter the vaginal microbiome and deplete the abundance of L. crispatus. Dr. Ravel's intensive medical knowledge set signifies that 9 out of 10 girls have an unstable vaginal microbiome, making them extra liable to problems akin to infections, odor, discharge and irritation. Though greater than two-thirds of girls report experiencing vaginal discomfort up to now 12 months,1 Obtainable merchandise usually goal signs solely and might additional alter the vaginal microbiome.
VS-01™ • Seeding the way forward for vaginal well being
Dr. Ravel's analysis not solely helped elucidate the essential position of L. crispatus in sustaining a protecting and steady vaginal microbiome, but in addition revealed that particular strains of L. crispatus They’re noticeably extra protecting and competent in selling vaginal well being.
Leveraging these discoveries, VS-01™ is formulated with an ecology of three patented properties. L. crispatus strains (LUCA103™, LUCA011™, LUCA009™), every recognized by key genomic traits that confer stability within the vaginal surroundings.
“Throughout my greater than twenty years of analysis on this area, I’ve seen numerous client merchandise that don’t handle the distinctive wants of the vaginal microbiome. Many probiotics geared toward vaginal well being use intestinal strains or are administered as oral dietary supplements, ignoring these strategies. they don't direct microbes from the gastrointestinal tract to the vagina,” Dr. Ravel stated. “I'm impressed to see Seed pioneer a brand new frontier in vaginal well being, translating my lab analysis into improvements that make an actual distinction in girls's lives.”
Past client purposes, Seed Well being is working with Dr. Ravel underneath LUCA Biologics to develop dwell biotherapeutics concentrating on the vaginal microbiome for unmet wants in urogenital and reproductive well being.
Clinically validated to revive an optimum vaginal microbiome
In a double-blind, randomized, placebo-controlled medical trial, VS-01™ established an optimum vaginal microbiome dominated by L. crispatus in 90% of members with a non-optimal vaginal microbiome inside a menstrual cycle. Full medical outcomes will probably be introduced on the 2024 annual convention of the Infectious Ailments Society of Obstetrics and Gynecology (IDSOG):
- Established an optimum vaginal microbiome: 90% of members established an optimum vaginal microbiome dominated by L. crispatus inside 21 days of use.
- Ineffectiveness of oral probiotic for vaginal well being: VS-01™ suppository pill quickly elevated the abundance of L. crispatus within the vaginal surroundings. In distinction, no strains of a number one oral probiotic for vaginal well being have been detected within the vagina on the finish of the research.
- Superior Supply Know-how: Seed's patented SMART Pill™ gives an extended-release profile that’s superior to each placebo and a rapid-release vaginal capsule with the identical strains.
- Safety: It has been proven to be properly tolerated and doesn’t alter vaginal pH.
“Seed's VS-01™ vaginal synbiotic is a scientific breakthrough that restores the vagina's tremendous defender, Lactobacillus curlatusdefending towards on a regular basis pH disruptors,” stated Diane HarperMD, Professor, Departments of Household Medication and Obstetrics and Gynecology College of Michigan, and internationally acknowledged vaginal well being skilled. “This development can empower girls to guard their vaginal well being.”
A brand new safety commonplace
VS-01™ redefines security requirements in vaginal well being merchandise, prioritizing the vaginal microbiome and necessary biomarkers that different merchandise don’t analyze. Utilizing a cruelty-free tissue mannequin acknowledged for preclinical validation by the Meals and Drug Administration (FDA), VS-01™ is examined for vaginal biocompatibility to make sure that the vaginal mucosal barrier just isn’t disrupted. Seed's complete security protocol additionally consists of testing for greater than 500 contaminants, together with chemical residues and heavy metals, and 14 lessons of allergens. VS-01™ is formulated with out synthetic fragrances, preservatives or colours and doesn’t include dairy or different animal-derived supplies. It's additionally vegan, cruelty-free, and excludes frequent endocrine disruptors like PFAS, parabens, BPA, and phthalates.
A protocol to handle the supply, not simply the signs
VS-01™ is designed to determine a vaginal microbiome dominated by L. crispatus and to take care of regulated pH and a wholesome vaginal surroundings for continued safety towards on a regular basis disruptors. VS-01™ begins with an intensive reset for the primary month to shortly set up an optimum vaginal microbiome and continues with month-to-month Maintain, a easy two-tablet month-to-month protocol to take care of a regulated vaginal pH and a steady vaginal microbiome.
VS-01M.T. The two month starter equipment is now accessible for $99with Maintain refills for $39.99 per 30 days in seed.com/vaginal-synbiotic. VS-01™ is HSA/FSA eligible and accessible at a reduced price to nurses, docs, college students, academics, first responders and army veterans.
About seed well being
Seed well being is a microbiome science firm pioneering improvements in probiotics and dwell medicines to influence human and planetary well being. Based to harness the potential of the microbiome, our platform allows the interpretation of progressive science right into a portfolio concentrating on well being outcomes from childhood to getting older. Our client improvements are marketed underneath Seed®: An award-winning, science-first model identified for clinically validated improvements in probiotics, together with DS-01® and PDS-08®. Our portfolio spans preventative and indication-specific purposes for gastrointestinal and digestive well being, girls's well being, pores and skin, pediatrics, mind well being, metabolic perform and wholesome getting older. Our environmental analysis is carried out underneath seed laboratorieswhich was based to advertise new bacterial interventions to enhance biodiversity and restore ecosystems affected by human exercise.
About Dr. Jacques Ravel
Dr. Jacques Ravel is Director of the Institute of Genome Sciences (IGS) and Professor of Microbiology and Immunology on the College of Maryland College of Medication, the place she applies fashionable omics applied sciences and ecological ideas to characterize the position of the vaginal microbiome in girls's well being. Her analysis is devoted to deciphering the mechanisms by which the vaginal microbiome protects towards infections and obstetric situations. Her work seeks to higher outline the interactions between hosts, microbial communities within the human physique, and environments that drive these ecological techniques, and leverage these findings to develop efficient interventions to modulate the composition and capabilities of the microbiome.
Dr. Ravel can also be co-founder and chief scientist of LUCA Biologics, a biotechnology firm growing a brand new class of dwell medicines concentrating on the vaginal microbiome to influence reproductive and urogenital well being.
Dr. Ravel is presently co-director of an NIH-funded collaborative analysis heart on 3D human biomimetic cervicovaginal fashions for sexually transmitted infections, which goals to develop an progressive biomimetic mannequin of the decrease reproductive tract to review points of sexually transmitted infections. sexual, chlamydia. and gonorrhea, which can’t be achieved in people or with present animal or mobile fashions. He has revealed greater than 330 peer-reviewed publications (62,595 citations) and has attracted extra $50 million on grants with steady federal funding since 2004. His laboratory is presently supported by grants from the US Nationwide Institutes of Well being, the Invoice & Melinda Gates Basis, in addition to the US Division of Agriculture.
He acquired his Ph.D. from the College of Maryland in Environmental Molecular Microbiology and Ecology and accomplished his postdoctoral coaching in Johns Hopkins College, engaged on the microbial chemistry of pure merchandise. In 2012, he was elected a Fellow of the American Academy of Microbiology (AAM) and in 2015 he acquired the Blaise Pascal Worldwide Analysis Chair, a prestigious European scientific honor. Dr. Ravel is the founding editor-in-chief of the journal. microbiome and affiliate editor of mBio journal.
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1 Based mostly on a survey performed in collaboration with YouGov an=3000 girls aged 18-55 occupied with vaginal well being.
SOURCE Seed Well being
